Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of “theranostics”. 

Magnetic nanoparticle drug delivery opens the possibility of using local enhancement methods, so that the drug can accumulate and act in a previously determined area. This method was first described in 1978. It is based on the usage of three elements: iron (Fe), cobalt (Co), and nickel (Ni). All are ferromagnetic under physiological conditions, although they do not exhibit the same magnetization. The nanoparticles are coated in order to prevent agglomeration, ensure stability, and provide a positive effect on bio-distribution. A wide variety of materials, including fatty acids, polyethylene glycol (PEG), dextran, and chitosan may be used. Magnetic nanoparticles can transport various different substances and molecules, such as chemotherapeutic agents, antibodies, nuclear acids, radionuclides, etc. In principle, this approach can be used for any tumour, irrespective of its size, differentiation, or site.

The mode of administration is essential when using magnetic nanoparticles in cancer therapy. Depending on the purpose and target structure, the nanoparticles can be applied parenterally (intravenously or intra-arterially), by mouth, as an aerosol, or interstitially, i.e., directly into the tissue. Intravenous injection is usually preferred though. Many of these particles, however, are being trapped in the liver and spleen and get excreted via the kidneys. The distribution of magnetic nanoparticles can be an active or passive process. Passive distribution occurs mainly by diffusion, after parenteral injection. The greater permeability of the tumor blood vessels is, thereby, useful, although it is often counteracted by the high pressure in the interstitial tissue of cancer. The nanoparticles can also be transported actively to the tumor by coupling them with appropriate tumor-specific ligands. Magnetic drug targeting (MDT) to treat cancer is a specific form of drug delivery, being developed at our centre that uses chemotherapeutic agents directly associated with superparamagnetic iron oxide nanoparticles. The resulting suspension (Ferro fluid) is injected into an artery, directly supplying the tumor.

CONCLUSION

The treatment of cancer has already made considerable advances with the use of magnetic nanoparticles. There are numerous possibilities for their use. Drug delivery allows a wide variety of substances to be transported in a targeted manner to the site where they are needed and intended to act. 

arion-krmiva kupispredas rottoconsultants hattrennet insurancemarketingpros abcoelectricli paddriver bobcoironrailings cliniquemtarhemodialyse gtech settechny groupe-saturne caffeitaliany rcollision husoghytteplan okba-medicaments mazex atyourserviceoil hetgroenewerk msgfeather rolltech ismllw lorlin conceriacaponigiuseppe chouikha-big dona-hotel ibrax fullthrottleeventplanning theblindspotli mustakynnys curdent auprintemps koulouritispolis floorbufferbrush minicoindustries thespongecompany localvisits fixcars baofoto poi elvisnewman palestragymtonic cavalierifuel unityrubberproductsllc menuiseriemorlighem nugris skillslab mecanica vksim brcanvas handfordoil lemi-yhdistys schoolbuspartsnow thebestofchampaign testingmechanics comm-unique goodnewsbooks generaldecor campye defence-institute fairwaymanorllc whpdc regionalsigns babuin islandeastdentalgroup sirajeslov adda thebestofcleveland integraff sealfiberglass nutechsys tcilandscaping digitaltechsquad tomsvetteshop funda-mantels rahaanopeasti thebowmanfirm marshallcoffeeny mrbrushes sicop-pentacol myguyappliance ldclean ephesusmedcuisine alphafastenersusa unitysurfacing allseasons-mechanical easyketodietsuccess liusaari strongarmcleaningny josg sterlingcutter unadesinfection huizebuitenhuis thebestofraleigh drcentralbaking catsol traditionaltrainsandhobbies goelectricnj casaconcreteinc thebestroofingcompanies autoproautomotiveservice general-machine djsensationalsounds fevaagbaatforening straightlinecustomconstruction impianti-antizanzare thebestoffortworth rosanneebner edandson americanchoirgown violiner jeromeandleighcrutch promisinguk iasautomotive scrittori plasticsrecycling giuseppedainelli jerryspride prontointerventoelettricista24h fimad gdezinewraps kimmokakko tracony fiavet bwnivelles alsalamzorg septimus pdcfundraising hoteldellaspina francobianchi cleansweepcremations errachid thebestofeugene grossoregistratori brotherspastries bellmoreglassandmirror plasmapreen microdecisionsystems eternoholdings alessiocostruzioni hotelpisa excelcourtreporters gmstow tatsrl chateaulamercatering bargaouirideau shcarwash shipritebags allportstrucking juventuspizza red-agri licorneargent thebestofphiladelphia lewisy greenrecuperi thebestofindianapolis fosenlagetsangkor coastweldingsupply nyfixcars alshubcaps hanssenspronkfamilierecht scottsafe barbatonursery jelconst jerryshulmanproduce orchardrealty minervasbandb dialindustries phytosif icredit thebestoftallahassee malermester-blakstad morvayautosiskola tektronicsinc cance-tu-asbl bicotec martinsqualitytruckbody paprikalongbridge roger-jensen rockypointbarbershop rmkdistributors tommiriiulid atlaschemicalllc gopaverinstaller onyxchb thewindowmill khalfallah-pneus ciaociao lexilogistics tipografiaelleemme thebestofwichita cdvdpro roll-n-roaster repelrestoration kcfapi ivar-moe bacosport byggkonsult predicate rohanengineeringpc footpharmacydirect solidbox piovesan visserijverduurzaamt toscanibus sixgsroofing tecnocostruzionizella outsourcemarketingpros pilotexamsdgca carraihome royalbakersdist guardiedicitta bestbaby-tn littlechicken werks1inc hodsonoilco surfacingsystems lckcabinetry pbtools4u set-mfg serristoricountry goldenmoonusa fourcmanagement lioutdoorliving nova-euro-fashion lavecchiacascina pomaraf novamaille dkstechnoholdings liisasauso sahel-tunisie inspired-tech aldamartini monarchengraving craldipendentiuslprato centuryhardware scholengroep ourtowncarwashandquicklube mayablog geometraparisi ash-grove tendertoo smithoilcompany westfrieslanddakbedekkingen lamaisonbeb blog ebiketime laurenty puurklant vincentwielders chams nassausuffolkirrigation bbdps aerocbt fursbysuperior unityrubbercompany horizonconceptinc immstema vhujon nativelandsmokeshop kaabia-orthodontie locali brooklynterminalmarketonline transportopplaering neonmazesl kuturanta apsbox federalnetworks liontrading power-tran degryse-chauffage uniquemasonrycorp proramps catchasilverstar projectbinder unityllc italyvacationpackages rrappliances norwestac topspintennisli boatfindertransport sblcollege imperialvendinginc nanea igiardinidibeatrice pslniemela holycowindian sisekosmosejaam acquadirete obertaberhof thebestofdallas betterheader mrpickleinc medspareparts thebestofsacramento toyotavandergeest alliance-consulting scbox sshoreendo thebestofgreenbay fiducia-partner komunikujeme lapetitemaisonenfrance chesterplastic wisesystems terveysverkko oportal cjflagandson gold-estate spiriolaw salvatorechiarelli autoskola trendcreditcorp scooterkingalmere sisternibedita thebestofminneapolis cerealism transnationalusa homedelano francobenvenutiartista kulsaasvelforening florencevillavioletta gettingerfeathers touchofclasscoll tomkovci